In a study of bacteria isolated from pleural fluid from 51 dogs, obligate anaerobes were isolated from 60 per cent of samples, and a mixture of obligate anaerobes and facultative anaerobes from 44 per cent (Walker and others 2000). The most common anaerobes isolated were Peptostreptococcus anaerobius, Bacteroides species and Fusobacterium species, and aerobes isolated were Actinomyces species, Pasteurella species, Escherichia coli and Streptococcus canis. Therefore, empirical antibiotics chosen for canine pyothorax should have activity against anaerobic and facultative bacteria, be distributed into the pleural space and have low toxicity.
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